I would be very interested in profiling T cells during pregnancy. The idea is to profile T cells in different tissues (placenta, uterus, livers, guts, spleens, meninges, etc.) in pregnant mice and compare them to those in the equivalent tissues (except for placenta) of non-pregnant virgin females. A growing number of studies (including those from us) suggest that a relatively short time window of pregnancy (e.g., 21 days in mice and 9 months in humans) can have huge impacts on immune cells, particularly T cells. Pregnant women are generally more susceptible to various infections (including respiratory viral infections), and developing fetuses are greatly influenced by the maternal immune system. It is imperative to understand how pregnancy shapes T cell responses and whether their altered function persists or desists following delivery. We want to profile T cells, if possible, from different tissues before, during, and after pregnancy. Ideas and suggestions are welcome.