It would be timely to compare and contrast the different COVID vaccines. Pfizer's or Moderna's mRNA vaccines seems to induce robust antibody response but then it wanes rather quickly (not sure if that is somehow dependent on the T cell response or not, and whether mice will be like humans). In contrast, Jannsen's adeno vaccine induces a more modest antibody response but it seems to last longer than mRNA vaccination. I believe the spike antigen is virtually identical thus it must be the vector/adjuvant that might be causing the difference: lipid nanoparticle vs adenoviral particle. The Novavax protein subunit vaccine apparently doesn't induce a T cell response, but I don't think it's known why.
It would be timely to compare and contrast the different COVID vaccines. Pfizer's or Moderna's mRNA vaccines seems to induce robust antibody response but then it wanes rather quickly (not sure if that is somehow dependent on the T cell response or not, and whether mice will be like humans). In contrast, Jannsen's adeno vaccine induces a more modest antibody response but it seems to last longer than mRNA vaccination. I believe the spike antigen is virtually identical thus it must be the vector/adjuvant that might be causing the difference: lipid nanoparticle vs adenoviral particle. The Novavax protein subunit vaccine apparently doesn't induce a T cell response, but I don't think it's known why.
Would be most grateful for specific suggestions